VEGF and angiogenesis in lung cancer
"...high VEGF levels have been correlated with poor prognosis in patients with lung cancer..."
— Herbst et al, J Clin Oncol, 20051
As observed in tumour malignancy in general, the process of angiogenesis, and in particular, VEGF, may play a critical role in tumour growth and metastasis of lung cancer. It has been shown that
- VEGF is significantly associated with increased MVD in lung cancer.2
- VEGF is overexpressed in a majority of NSCLC tumours.3
- VEGF is expressed at higher levels as lung cancer progresses.4
- VEGF may be correlated with carcinogens in lung cancer.5
- VEGF overexpression has been associated with decreased survival in lung cancer.2,6
In this section, you will find information on the prevalence of VEGF expression in lung cancer, the relationship between VEGF expression and PD, correlation of VEGF with carcinogens and VEGF as a prognostic factor in lung cancer.
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