Summary: VEGF in lung cancer
The importance of VEGF and angiogenesis in lung cancer development is supported by a large and growing body of literature
- VEGF expression has been observed in all forms of NSCLC, including adenocarcinoma, squamous cell carcinoma and large cell carcinoma.
- VEGF expression has also been correlated directly with increased microvessel counts.
- Notably, a recent study suggests a correlation between VEGF and nicotine, a carcinogen linked to lung cancer.
Overall, VEGF overexpression and increased MVD have been associated with poor outcomes in lung cancer.
Large prospective studies are necessary to better define the relationship of prognosis to angiogenesis and VEGF.
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