Immune response and other effects
VEGF may prevent immune response to tumours
Tumours have developed a variety of mechanisms to avoid immune responses. One of these mechanisms involves the inhibition of dendritic cells, which are antigen-presenting cells that stimulate B cells and T cells. Recently, it has been demonstrated in vitro that VEGF can prevent the functional maturation of dendritic cells from their haematopoietic progenitors. Tumour secretion of VEGF may play an important role in suppressing the immune antitumoural response.62
VEGF has multiple other effects
The effects of tumoural expression of VEGF are currently being investigated in dendritic cells and haematopoietic stem cells.
- Disclaimer: Avastin.net is a comprehensive resource for healthcare professionals outside the US. If you are a US resident please visit www.avastin.comThe information on this site is not country-specific and may contain information that is outside the approved indications in the country in which you are located.