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VEGF and angiogenesis
Angiogenesis is essential to tumour development
The angiogenic process
Angiogenesis in tumour growth
VEGF: the predominant regulator of angiogenesis
The VEGF pathway
Environmental and cellular triggers of VEGF
VEGF expression / angiogenic switch
Interactions of VEGF ligands and VEGFRs
Post-receptor signalling
VEGF in tumour growth
Growth and survival of tumour vessels
Formation of abnormal vasculature
Increase in interstitial pressure
Immune response and other effects
History of VEGF research
Landmark papers
Role of Genentech and Roche
Summary
References
Approaches to VEGF inhibition
Strategies for VEGF inhibition
Proposed MoA of anti-VEGF agents
Versatility to address changing tumour biology
Summary
References
Continuous VEGF inhibition
Stability of VEGF and endothelial cells
VEGF expression is continuous
Understanding tumour progression
Summary
References
The role of VEGF across tumour types
VEGF in breast cancer
VEGF expression in breast cancer
VEGF: a critical pro-angiogenic factor
VEGF in breast malignancy development
VEGF and MVD
Pattern of angiogenesis
VEGF and other tumour markers
VEGF and oestrogen
VEGF and HER-2
VEGF and BRCA-1
VEGF beyond angiogenesis
Prevalence of VEGF-expressing breast cancers
VEGF and metastasis
VEGF and prognosis
VEGF as a predictive factor
Summary
References
VEGF in lung cancer
Prevalence of VEGF expression
VEGF expression
Disease progression
Vasculature location
VEGF and carcinogens
VEGF and prognosis
Malignant pleural effusion
Survival
Summary
References
VEGF in RCC
Biology of RCC
Ubiquitination
VEGF in RCC pathogenesis
VEGF expression
VEGF and prognosis
Summary
References
VEGF in ovarian cancer
VEGF in the reproductive cycle
VEGF expression
VEGF in ovarian cancer development
VEGF and prognosis
Summary
References
Slide decks and videos
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History of VEGF and angiogenesis research
Timeline of research milestones