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Summary: precise VEGF inhibition by Avastin limits toxicity

  • The side effects of biological agents are related to their MoA and specificity.
  • Avastin inhibits only the VEGF pathway through extracelllular ligand binding
    • side effects attributed to Avastin can be directly linked to inhibition of the VEGF pathway.
  • The safety profile of Avastin is well known and based on experience in a large number of patients
    • this profile does not generally overlap with those of other types of therapy, thereby making Avastin an excellent combination partner for a wide spectrum of standard therapies.