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Science of VEGF
Avastin MoA
Understanding the Avastin MoA
Avastin regresses vasculature
Regression increases tumour response
Avastin normalises vasculature
Normalisation maximises efficacy
Avastin inhibits vessel growth
Inhibition provides continued disease control
Summary
References
Avastin controls tumour growth
Efficacy of Avastin
Efficacy across tumours
Avastin provides benefit in several tumour types
Why search for a biomarker?
The search for a predictive biomarker
All patient subgroups can benefit
Combinability with a range of therapies
Conventional chemotherapy
Other treatment modalities
Summary
References
Optimal duration of Avastin therapy
Treatment until PD
Summary
References
Limits toxicity
The safety profile of Avastin
The safety profile of Avastin does not overlap
The safety profile of Avastin in CNS metastases
Summary
References
Labelling information
Avastin in NSCLC
First-line treatment
AVF0757g
Efficacy
Safety
ECOG 4599
OS
PFS and ORR
OS in adenocarcinoma
Patient subgroups
Safety
AVAiL
PFS
PFS in maintenance
Patient subgroups
ORR
Safety
SAiL
Safety
AEs of special interest
Efficacy
Efficacy in the elderly
ARIES
Preliminary results
Extending the benefit
Waples, et al.
Patel, et al.
AVAPERL1
PointBreak
ATLAS
BeTa lung
Additional areas of investigation
Summary
References
Avastin in mBC
E2100
PFS
PFS in patient subgroups
PFS by prior therapy
Response rate
Survival
QoL
Safety
AVADO
PFS
PFS in patient subgroups
Response rate
Survival
QoL
Safety
Current and future developments
Predictive biomarkers
Summary
References
Avastin in mCRC
First-line treatment
AVF2107g
OS
OS in patient subgroups
PFS
ORR
Safety
AEs
NO16966
PFS
OS
ORR
Safety
BRiTE
Safety
PFS and OS
First-BEAT
Safety
OS
PFS
Safety and efficacy in the elderly
Second-line treatment
E3200
OS
PFS
ORR
Safety
References
Avastin in mRCC
Introduction
RCC is VEGF-driven
Current treatment landscape
First-line Avastin plus IFN
AVOREN
PFS
PFS as an endpoint
Response rates
OS
Prognostic factors
Safety
Tolerability
Avastin plus reduced-dose IFN tolerability
Avastin plus reduced-dose IFN efficacy
Summary
References
Slide decks and videos
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Abbreviations
SAiL: proven efficacy in the elderly population
SAiL: efficacy data in patients ≤65 years and >65 years of age
14
Reprinted with the kind permission of the author.
Approximately 28% of patients evaluable for safety were >65 years of age.
The median age for the elderly (>65 years) group was 70.
Compared with patients aged ≤65 years,
elderly patients
(>65 years) treated with first-line Avastin-based therapy
had a
similar incidence of AEs of special interest
had
similar efficacy
outcomes,
with a
remarkable median OS of 14.6
months in both populations.
14
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