Combining Avastin with conventional chemotherapy leads to superior efficacy
- The specific chemotherapy agents used in clinical practice vary considerably between tumour types; trials have investigated Avastin in combination with the most frequently used regimens in each indication.
- Avastin has demonstrated efficacy in phase III trials when combined with a variety of chemotherapy agents and regimens
- mCRC: IFL, XELOX, FOLFOX47,28
- NSCLC: carboplatin/paclitaxel, cisplatin/gemcitabine8,12
- mBC: paclitaxel, docetaxel.9,14
- Large safety studies have explored further combinations in mCRC, NSCLC and mBC.29–32
Chemotherapy agents and regimens used in combination with Avastin in safety studies29–32