Avastin.net

Avastin inhibits new and recurrent vessel growth

Avastin (A4.6.1) reduces new tumour vessel diameter and vascular area⁹

In vivo, the murine Avastin equivalent (A4.6.1) significantly reduces new tumour vessel diameter (A) and vascular area (B) to the level present in underlying healthy skeletal muscle.⁹

Reprinted with permission from Borgström P, et al. Cancer Res 1996;56:4032–9, Figure 8.

• In preclinical models, Avastin alone resulted in nearly complete inhibition of new vessel growth,^9,10 which is required for tumour growth and metastasis.²³

• The inhibition of neovascularisation with Avastin has been correlated with decreased tumour growth and metastatic potential.¹³

• In addition, Avastin may result in ongoing inhibition of recurrent tumour vessel growth.^9,10

• In terms of clinical significance, inhibition of recurrent tumour vessel growth by Avastin can provide continued disease control. This effect is discussed in more detail here.